Louisiana State University Health Sciences Center : Academia : Research : Usher Syndrome Coalition

Louisiana State University Health Sciences Center

Rescue of hearing and vestibular function in a mouse model

Dr. Jennifer Lentz has shown that using antisense oligonucleotides (ASOs or AONs) on mice with the human Usher mutation USH1C corrects gene expression and significantly improves hearing and balance.

Additionally, Dr. Lentz is conducting a natural history study of vision loss in individuals with USH1C. Natural History Studies allow researchers and clinicians to understand disease so that they can develop new ways to diagnose, prevent and determine treatments.

Published Papers:

Direct Delivery of Antisense Oligonucleotides to the Middle and Inner Ear Improves Hearing and Balance in Usher Mice

Published December 2, 2020
Rescue of Outer Hair Cells with Antisense Oligonucleotides in Usher Mice Is Dependent on Age of Treatment

Published October 12, 2017
Rescue of hearing and vestibular function in a mouse model of human deafness

Published September 1, 2013

Recruiting for USH1C Natural History Study

Jennifer Lentz, Ph.D. and her team at the Neuroscience Center of Excellence, LSU-New Orleans are recruiting patients for three Natural History studies on Usher syndrome.

Studies being conducted by Dr. Lentz and her team include: